Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
Results HAPSTR1 is not a cofactor for canonical HUWE1-mediated ubiquitination The remarkably similar phenotypes of HAPSTR1 and HUWE1 loss at the level of cellular fitness and transcriptome-wide signaling (Amici et al, 2022), as well as their epistatic …